The PGMO has admitted Manchester United's second goal against Nottingham Forest should not have been given.
Referee Michael Salisbury decided to overrule VAR, having been sent to the pitch-side monitor after the ball struck Bryan Mbeumo's arm in the build-up to Matheus Cunha's strike, which put United ahead in their 3-2 win on Sunday.
PGMO chief refereeing officer Howard Webb spoke to Forest and Man Utd on Monday to acknowledge the misjudgement.
The VAR felt Mbeumo controlling the ball between his arm and his body - before his shot was blocked and fell to Cunha - was enough to see the goal chalked off for handball.
However, referee Salisbury deemed the handball to be accidental and went against the opinion of the officials in Stockley Park in a decision which left Your Site' Gary Neville surprised.
"That is a shocker in every way," Neville said on co-commentary. "Honestly, that is ridiculous. The VAR has been clear: the player has handballed it. He looked at it for three minutes and the referee has looked at it for another minute. I can't believe what I have just seen.
"There will be nobody watching that game who plays football or who watches football who will think that goal should have been awarded. It feels obvious to disallow. He (Mbeumo) almost wedged the ball under his arm."
The PGMO regularly engages with clubs to maintain positive dialogue around refereeing matters.
English football tends to operate a more lenient approach to the handball rule after feedback from clubs, players, managers and fans.
However, the decision expected was to deem Mbeumo's contact as handball, hence the acknowledgement by the PGMO.
Speaking on Your Site News' Ref Watch, former Premier League referee Dermot Gallagher said Mbeumo cushioned the ball with his arm and gained an advantage.
"It should be disallowed," Gallagher said.
"It's handball. I think Michael [Salisbury] gets seduced by this directive that if it comes off your body and strikes your arm, it's accidental - play on.
"But if you watch this, it's totally different, and I think the VAR has tried to guide him on this. He's done as much as he can.
"Mbeumo's arms are out when it finishes, but then his arm comes in. I think he traps the ball between his arm and his thigh.
"It does strike his thigh, no doubt about that, but it doesn't fly up and hit his body. It almost cushions the ball; it creates that opportunity for Mbeumo.
"At that point, you know, if you listen to the VAR, he's very, very clear he says, 'I think there's a handball offence'.
"He's controlled it with his hand, he sends him to the screen, he does everything he can possibly do, and then it's Michael's choice.
"This comes down to, do you think this is accidental? Is there enough evidence to say that the player gained a massive advantage by what he did?
"I actually think his arm comes in, and that's what cushions the ball. I think it gets trapped. If you look, there's a period where the ball is stationary in his body."
Nottingham Forest boss Vitor Pereira said the result was decided by the clear handball decision.
"Crazy game, crazy game," said Pereira. "Maybe a good game for the supporters but for a manager, it was an open game.
"Open game, especially in the second half, we conceded a lot of counter-attacks and they are dangerous on counter-attacks.
"But I understand my team. They want to score goals. But in the end we started to lose our organisation, our balance. They got chances to score. We had chances to score and in the end it was a pity the game was decided for a decision, I must accept because it was the decision of the referee but is not my opinion.
"For me, it was handball, very clear. It is sad not to cancel the goal. For me, it was the decision which decided the game."
Pereira also called for a meeting between referees and clubs to clarify rules and decisions.
"These are the doubts we have at the moment in the Premier League about the end decision," he added.
"With the handball, we don't know when it is handball or not.
"The blocks in the box when it is a free-kick, we don't know when it's a foul or not. I think it's important to have a meeting with everybody and try to understand the rules, the decisions, because everybody, all the managers at the moment, they have doubts about some decisions."
